Omega-3 PUFAs and the Gut-Brain Axis in Depression: Immune Resolution and HPA Modulation

Authors: Review

Published: January 1, 1970

Synthesizes how EPA and DHA may exert effects through the gut-brain axis - shaping microbiota, reducing intestinal permeability and immune activation, and modulating HPA-axis stress signaling. Notes individuals with mood disorders often show reduced EPA/DHA membrane levels. Presented as mechanism and active inquiry, not settled cure.